Methods and compounds for prevention of graft rejection
US5958403A · kind A · utility
37Cited by
2References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 11, 1994 |
| Grant date | Sep 28, 1999 |
| Priority date | — |
| Expiry date | Jul 11, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method of localized immunosuppression which may be used for preventing graft rejection or for preventing tissue destruction due to autoimmune disease. Also disclosed is a protein suppressor factor that is secreted by cloned anergic T-cells, blocks interleukin 2 (IL-2) stimulated T-cell proliferation, has an apparent molecular weight of between 10 and 30 kilodaltons, can be inactivated by heating to 65.degree. C. for 15 minute, blocks interleukin 4 (IL-4) stimulated T-cell proliferation in vitro, is non-cytotoxic to T-cells, and does not inhibit the production of IL-2 by T-cells in vitro.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.