Thin film composition with biological substance and method of making
US5958430A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 20, 1998 |
| Grant date | Sep 28, 1999 |
| Priority date | — |
| Expiry date | Feb 20, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached to the attachment sites of the underlying substrate; and a thin film of a second material deposited onto the attachment sites of the underlying substrate, and a biologically active substance deposited with the thin-film. Preferably the functional groups are attached to a self assembling monolayer attached to the underlying substrate. Preferred functional groups attached to the underlying substrate are chosen from the group consisting of carboxylates, sulfonates, phosphates, optionally substituted, linear or cyclo, alkyl, alkene, alkyne, aryl, alkylaryl, amine, hydroxyl, thiol, silyl, phosphoryl, cyano, metallocenyl, carbonyl, and polyphosphate. Preferred materials for the underlying substrate are selected from the group consisting of a metal, a metal alloy, a plastic, a polymer, a proteic film, a membrane, a glass or a ceramic. The second material is selected from the group consisting of inorganic crystalline structures, inorganic amorphus structures, organic crystalline structures, and …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.