Use of modified tethers in screening compound libraries
US5958703A · kind A · utility
325Cited by
5References
44Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 3, 1996 |
| Grant date | Sep 28, 1999 |
| Priority date | — |
| Expiry date | Dec 3, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.