Sensing system for specific substance and molecule detection
US5958704A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1997 |
| Grant date | Sep 28, 1999 |
| Priority date | — |
| Expiry date | Mar 12, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/116664
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least one capture layer that includes a ligand layer. In one embodiment, the attachment layer is tripartite and includes a lower binding surface held to the substrate and an upper binding surface that holds the ligand layer, together with an insulating layer disposed between these two surfaces. The lower binding surface provides a durable and stable attachment to the substrate. The upper binding surface holds the ligand layer and does not jeopardize the integrity or viability thereof. The insulating layer prevents any unwanted interaction between the lower and upper binding surfaces. Each sensing unit is supported on a test piece received by the instrument. The instrument controllably positions the test piece using marks and/or codes on the test piece. The instrument measures a difference in mass in the sensing unit in connection with determining whether or not the analyte of interest is present. A light beam is used in making this measur…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.