Predicting folded structures of proteins
US5958784A · kind A · utility
Inventor
Key dates
| Filing date | Mar 25, 1992 |
| Grant date | Sep 28, 1999 |
| Priority date | — |
| Expiry date | Mar 25, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6803
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method is presented for predicting the folded structure of proteins that comprises obtaining an alignment of the sequences of a set of homologous proteins, using patterns of conservation and variation of the sequence between proteins with clearly defined evolutionary relationships to assign positions in the alignment to the surface of the folded structure, the inside of the folded structure, active site, or parsing segments, assigning secondary structures by identifying periodicity in said assignments, and then assembling the secondary structural units into a globular form using distance constraints imposed by disulfide bridges, active site assignments, and covariation analysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.