Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
US5959085A · kind A · utility
62Cited by
1References
8Claims
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Assignee
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Key dates
| Filing date | May 16, 1996 |
| Grant date | Sep 28, 1999 |
| Priority date | — |
| Expiry date | May 16, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/21
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Human monoclonal antibodies against a human cytokine (such as a human interleukin, e.g., human IL-1.alpha.) and fragments of such antibodies are disclosed. Also disclosed are pharmaceutical compositions and methods employing the human monoclonal antibodies and fragments, methods for screening for human monoclonal antibodies against a human protein, methods for producing a cDNA library enriched in DNA encoding V.sub.H and/or V.sub.L chains of a human monoclonal antibody, cell lines for making the human monoclonal antibodies, and isolated DNA for making the human monoclonal antibodies and fragments of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.