Submicron emulsions as vaccine adjuvants

US5961970A · kind A · utility

Assignees

• Pharmos Corporation · US
• The United States of America as represented by the Secretary of the Army · US

Inventors

• George H. Lowell · Baltimore, US
• Shimon Amselem · Rehovot, IL
• Doron Friedman · Karmei Yosef, IL
• Haim Aviv · Rehovot, IL

Key dates

• Filing date: Apr 29, 1996
• Grant date: Oct 5, 1999
• Expiry date: Apr 29, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/918
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A vaccine adjuvant composition of an oil-in-water submicron emulsion that has about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, about 0.05 to 5% of a nonionic surfactant, about 0.00001 to 1% of an immunogen, and an aqueous continuous phase. This submicron emulsion has a mean droplet size in the range of between about 0.03 and 0.5 .mu.m, and preferably 0.05 and 0.2 .mu.m.