Methods of predicting estrogen-dependent osteopenia
US5962242A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 22, 1997 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Aug 22, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/36
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Diagnostic/prognostic methods are provided for screening for pathologies wherein an alteration in estrogen metabolism is indicative of a pathology or a susceptibility thereto which comprise detecting and/or quantifying directly in tissues and body fluids of mammals abnormal levels of estrone metabolites and their glucuronide conjugates. Particularly preferred methods involve the use of the 16OHE1-glucuronide fraction, i.e., the fraction which contains 16.alpha.-hydroxyestrone (16OHE1) and its conjugates, 16OHE1-3-glucuronide. Methods of preparing reagents to detect said 16OHE1-glucuronide fraction in tissues and body fluids are disclosed as well as test kits for performing the disclosed assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.