dUTPase, its isoforms, and diagnostic and other uses
US5962246A · kind A · utility
61Cited by
1References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 26, 1997 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Mar 26, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/14
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides the DNA and amino acid sequence of dUTPase, an enzyme which is essential for life and which is increased during periods of cellular proliferation. The human form of the dUTPase enzyme has been found to have two isoforms, a nuclear and a mitochondrial isoform. Methods of determining the proliferation status of a cell, efficacy of antineoplastic compounds, and response to therapy with antineoplastic compounds, using cellular levels of dUTPase is disclosed. A kit containing the necessary reagents for the determination of dUTPase is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.