Inhibition of selectin binding

US5962422A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Jon O. Nagy · Rodeo, US
• Wayne Spevak · Berkeley, US
• Falguni Dasgupta · San Leandro, US
• Carolyn R. Bertozzi · Berkeley, US

Key dates

• Filing date: Feb 28, 1997
• Grant date: Oct 5, 1999
• Expiry date: Feb 28, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.