In vivo gene transfer methods for wound healing
US5962427A · kind A · utility
73Cited by
165References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1996 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Apr 12, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.