Complexes of adenovirus with cationic molecules
US5962429A · kind A · utility
12Cited by
3References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1996 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Nov 22, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides noncovalent complexes of cationic molecules and adenoviral vectors containing a transgene. The complexes of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the complexes are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to a CF patient utilizing a complex of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.