Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5962435A · kind A · utility
58Cited by
32References
10Claims
0Family size
Assignee
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Key dates
| Filing date | May 12, 1997 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | May 12, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/081
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of lowering plasma cholesterol level in a patient with hypercholesterolemia, by administration of a compound of formula (1) ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group; PA1 Z is a thio, oxy or methylene group; PA1 A is a C.sub.1 -C.sub.4 alkylene group; and PA1 R.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.