Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein
US5962463A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 1997 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Jan 27, 2017 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stimulating non-amyloidogenic processing by the activation of cell surface serotonin receptors linked to phospholipase and protein kinase C is described. Activation of the cell surface serotonin receptors is accomplished by contacting the cell with an agent which is a serotonin agonist or which increases the intrasynaptic concentration of serotonin. Also described is the activation of cell surface serotonin receptors by dexnorfenfluramine. Agents which cause the activation of cell surface serotonin receptors can be administered to an individual to stimulate non-amyloidogenic processing in the brain of the individual, thereby inhibiting the deposition of amyloid in the brain of the individual.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.