Indole derivatives as prodrugs of 5-HT.sub.1 -like receptor agonists

US5962486A · kind A · utility

Assignee

• Zeneca Limited · GB

Inventors

• Robert J. Blade · Tring, GB
• Yih Sang Pang · Stevenage, GB
• David Selwood · London, GB

Key dates

• Filing date: Nov 22, 1996
• Grant date: Oct 5, 1999
• Expiry date: Nov 22, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I), wherein A is C.sub.1-6 alkyl, --O--C.sub.1-6 alkyl, --O--phenyl or phenyl, optionally substituted by C.sub.1-3 alkyl or halogen; n is an integer of from 0 to 3; W is a group of formula (i), (ii) or (iii) where R is hydrogen or C.sub.1-4 alkyl, x is --O--, --S--, --NH--, or --CH.sub.2 --, Y is oxygen or sulphur and the chiral centre * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; and Z is a group of formula (iv) --HC.sub.2 CH.sub.2 NR.sup.1 R.sup.2 (v) or (vi) where R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1-4 alkyl and R.sup.3 is hydrogen or C.sub.1-4 alkyl; and salts, solvates and physiologically functional derivatives thereof. ##STR1##