O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds, and their use, as well as a method of preparing them

US5962507A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Eberhard Woitun · Biberach an der Riß, DE
• Roland Maier · Biberach an der Riß, DE
• Peter Muller · Mittelbiberach, DE
• Rudolf Hurnaus · Großenhain, DE
• Michael Mark · Biberach an der Riß, DE
• Bernard Eisele · Biberach, DE
• Ralph-Michael Budzinski · Biberach, DE
• Gerhard Hallermayer · Biberach an der Riß, DE

Key dates

• Filing date: Dec 5, 1997
• Grant date: Oct 5, 1999
• Expiry date: Dec 5, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R.sup.1 and R.sup.2 each denote hydrogen, lower alkyl, alkenyl or alkynyl, which may optionally also be substituted, or together with the nitrogen atom between the denote 5- to 7-membered saturated, monocyclic or heterocyclic rings which may optionally also be interrupted by an oxygen or sulfur atom or by an imino group, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 denote hydrogen or lower alkyl, R.sup.5 additionally denotes lower alkoxy, R.sup.7 denotes hydrogen, cycloalkyl, phenyl or substituted phenyl, naphthyl, tetrahydronaphthyl, thienyl, furyl or pyridyl and A denotes a chemical bond or alkyl, alkenyl having up to 17 carbon atoms.