Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery

US5962566A · kind A · utility

Assignee

• The European Community · BE

Inventors

• Christian GRANDFILS · Liège, BE
• Robert Jerome · Tilff, BE
• Nicole Nihant · Battice, BE
• Philippe Teyssie · Flémalle, BE

Key dates

• Filing date: May 7, 1998
• Grant date: Oct 5, 1999
• Expiry date: May 7, 2018

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/801
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The presently claimed invention comprises a biopolymer nanoparticle for drug delivery wherein the nanoparticle comprises a homogeneous blend of an aliphatic polyester polymer blended with a polyether, a lipophilic or polypeptide drug and a biocompatible cholesterol interacting agent for preserving the activity of the drug administered to the patient while at the same time controlling the release of the drug. Methods for making the homogeneous drug delivery nanoparticles are also disclosed.