Production of human recombinant collagen in the milk of transgenic mammals
US5962648A · kind A · utility
10Cited by
7References
3Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/832
- WIPO fieldFood chemistry
- WIPO sectorChemistry
Abstract
Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.