Pharmaco-gene delivery in human breast cancer cells
US5962667A · kind A · utility
5Cited by
7References
10Claims
0Family size
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Key dates
| Filing date | Nov 3, 1997 |
| Grant date | Oct 5, 1999 |
| Priority date | — |
| Expiry date | Nov 3, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J1/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Estradiol facilitates non-viral gene delivery to breast tumor cells. The effect is dose dependent, and is independent of the gene construct, temperature, and tumor cell line. Thus, compositions and treatment regimens that use estradiol, or other estrogen pharmacologic agents, in combination with genes of interest can be used to provide targeted delivery and expression of genetic products in target cells and tissues of estrogen, such as breast cells. The compositions and treatment regimens have particular application to the enhanced delivery of genetic constructs useful in killing breast tumor cells and preventing tumor recurrence.
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