Methods and compositions for targeting the vasculature of solid tumors
US5965132A · kind A · utility
85Cited by
14References
16Claims
0Family size
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Key dates
| Filing date | Dec 5, 1994 |
| Grant date | Oct 12, 1999 |
| Priority date | — |
| Expiry date | Dec 5, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/828
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.