Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds
US5965434A · kind A · utility
138Cited by
1References
14Claims
0Family size
Inventors
Key dates
| Filing date | Dec 29, 1994 |
| Grant date | Oct 12, 1999 |
| Priority date | — |
| Expiry date | Dec 29, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides amphipathic lipid compounds comprising a hydrophilic, catonic, pH-sensitive moiety, the positive charge of which moiety increases as pH decreases over the pH range of 8.0 to 4.5. Vesicular delivery systems comprising such amphipathic compounds and the use of those systems for delivering biologically active substances to cells are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.