Preparation of active peptides

US5965700A · kind A · utility

Assignee

• BASF SE

Inventors

• Wilhelm Amberg · Ludwigshafen, DE
• Harald Bernard · Bad Dürkheim, DE
• Ernst Buschmann · Ludwigshafen, DE
• Andreas Haupt · Ludwigshafen, DE
• Bernd Janssen · Ludwigshafen, DE
• Ulrich Karl · Havelsee, DE
• Andreas Kling · Mannheim, DE
• Stefan Muller · Weil am Rhein, DE
• Kurt Ritter · Heidelberg, DE
• Thomas Zierke · Böhl-Iggelheim, DE

Key dates

• Filing date: Jan 13, 1998
• Grant date: Oct 12, 1999
• Expiry date: Jan 13, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/101
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for preparing pentapeptides of the formula I ##STR1## where A and R.sup.1 -R.sup.3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II ##STR2## where R.sup.1 and R.sup.2 have the abovementioned meanings, and eliminating the group --NR.sup.1 R.sup.2 by hydrolysis where appropriate the peptide obtained in this way.