Antibodies with binding affinity for the CD3 antigen
US5968509A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 23, 1994 |
| Grant date | Oct 19, 1999 |
| Priority date | — |
| Expiry date | Dec 23, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antibody or antibody fragment with a binding affinity for the CD3 antigen, having a human constant region, and human or rat variable framework region, a heavy chain with CDRs having the amino acid sequences: PA1 (a) Ser-Phe-Pro-Met-Ala (SEQ ID NO:1), PA1 (b) Thr-Ile-Ser-The-Ser-Gly-Gly-Arg-Thr-Tyr-Tyr-Arg-Asp-Ser-Val-Lys-Gly (SEQ ID NO:2), PA1 (c) Phe-Arg-Gln-Tyr-Ser-Gly-Gly-Phe-Asp-Tyr (SEQ ID NO:3), and light chain with CDRs having the amino acid sequences: PA1 (d) Thr-Leu-Ser-Ser-Gly-Asn-Ile-Glu-Asn-Tyr-Val-His (SEQ ID NO:4), PA1 (e) Asp-Asp-Asp-Lys-Arg-Pro-Asp (SEQ ID NO:5), PA1 (f) His-Ser-Tyr-Val-Ser-Ser-Phe-Asn-Val (SEQ ID NO:6), in which the heavy chain CDRs are arranged in the order (a), (b), (c) in the leader.fwdarw.constant region direction and the light chain CDRs are arranged in the order (d), (e), (f) in the leader.fwdarw.constant region direction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.