Nucleic acid corresponding to a gene of chromosome 22 involved in recurrent chromosomal translocations associated with the development of cancerous tumors, and nucleic acids of fusion resulting from said translocations

US5968734A · kind A · utility

Assignee

• CNRS-CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Alain Aurias · Les Ulis, FR
• Olivier Delattre · Paris, FR
• Chantal Desmaze · Saran, FR
• Thomas Melot · Brunoy, FR
• Martine PETER · Noisy-le-Grand, FR
• Beatrice Ploougastel · Paris, FR
• Gilles Thomas · Paris, FR
• Jessica Zucman · Clichy, FR

Key dates

• Filing date: Jan 18, 1995
• Grant date: Oct 19, 1999
• Expiry date: Jan 18, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Translocations of chromosome 22 are associated with various cancers. Hybrid DNA sequences, having a portion of the Ews gene of chromosome 22 and a portion of either the Hum-Fli-1 gene of chromosome 11, the Erg gene of chromosome 21, or the Atf-1 gene of chromosome 12, are disclosed. Proteins encoded by these hybrid DNAs are disclosed. Diagnosis of specific cancers based on detection of the translocations is disclosed.