Method for identifying an OP-1 analog which binds an ALK-1 receptor
US5968752A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 13, 1996 |
| Grant date | Oct 19, 1999 |
| Priority date | — |
| Expiry date | Aug 13, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features, and various other data characterizing morphogen cell surface receptors, particularly OP-1-binding cell surface receptors, e.g., ALK-1; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying and producing morphogen analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic, and experimental uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.