Method for screening inhibitors of the enzyme which cleaves the anchor of surface proteins from gram positive bacteria
US5968763A · kind A · utility
39Cited by
2References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 17, 1997 |
| Grant date | Oct 19, 1999 |
| Priority date | — |
| Expiry date | Mar 17, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to an enzyme which cleaves surface proteins of gram-positive bacteria, to methods of detecting the enzyme, and methods of isolating the enzyme. In particular, the enzyme is isolated from a group A Streptococcus, and cleaves at the sequence LPXTGX (SEQ ID NO:1). A method for screening putative inhibitors of the enzyme which cleaves the anchor region of surface proteins from gram positive bacteria is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.