Benzenesulfonamide derivatives as bradykinin antagonists
US5968951A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 31, 1997 |
| Grant date | Oct 19, 1999 |
| Priority date | — |
| Expiry date | Jan 31, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel compounds of the formula in which: PA0 X is a halogen atom, PA0 R.sub.1 and R.sub.2, which are identical or different, are each --H or --A--B--R.sub.3, PA0 A is a linear or branched C.sub.1 -C.sub.12 -alkylene chain, PA0 B is a single bond, a divalent phenylene group or a divalent indolyl group of the structure ##STR1## R.sub.3 is --H, --OH, --NR.sub.4 R.sub.5 or --COR.sub.6, R.sub.6 is --OH, --OCH.sub.3, --OC.sub.2 H.sub.5 or --NR.sub.4 R.sub.5, PA0 R.sub.4 and R.sub.5, which are identical or different, are each H, a C.sub.1 -C.sub.4 -alkyl group, --(CH.sub.2).sub.n --OH, --(CH.sub.2).sub.n --N(CH.sub.3).sub.2 or --CO--CH.sub.3, and n is an integer with a value of 2, 3 or 4; and their addition salts. It further relates to their preparation and to their use in therapeutics, especially for the treatment of pathological conditions involving bradykinin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.