Biphenylsulfonylcyanamides, process for their preparation, and their use as medicament

US5968978A · kind A · utility

Assignee

• Hoechst Marion Roussel Deutschland GmbH · DE

Inventors

• Heinz-Werner Kleemann · Bischofsheim, DE
• Jan-Robert Schwark · Frankfurt am Main, DE
• Sabine Faber · Idstein, DE
• Hans-Jochen Lang · Hofheim, DE
• Andreas Weichert · Egelsbach, DE
• Hans-Willi Jansen · Niedernhausen, DE

Key dates

• Filing date: Sep 21, 1998
• Grant date: Oct 19, 1999
• Expiry date: Sep 21, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## in which the symbols have the meanings indicated in the claims, have outstanding antiarrhythmic properties. They exhibit a cardioprotective component. They can inhibit or greatly decrease, in a preventive manner, the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias. Moreover, they have a strong inhibitory action on the proliferation of cells.