Bioreductive cytotoxic agents

US5969133A · kind A · utility

Assignee

• Shionogi Bioresearch Corp. · US

Inventors

• Mitsunori Ono · Lexington, US
• Keizo Koya · Sharon, US
• Lijun Sun · Harvard, US
• Yumiko Wada · Waltham, US
• Wojciech Wrona · Cambridge, US
• Natalie Dales · Arlington, US
• Xueliang Tao · Arlington, US
• Sylvia Holden · Woburn, US

Key dates

• Filing date: May 22, 1998
• Grant date: Oct 19, 1999
• Expiry date: May 22, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound which consists of a proactive alkylating moiety containing an electron-withdrawing group, a bioreductive moiety containing at least two double bonds, and a linker joining the proactive alkylating moiety and the bioreductive moiety.