Ortho-quinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth
US5969163A · kind A · utility
24Cited by
3References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 9, 1997 |
| Grant date | Oct 19, 1999 |
| Priority date | — |
| Expiry date | Oct 9, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for the preparation of .beta.-lapachone and dunnione derivatives of formulae I and II ##STR1## wherein, the a solution of lawsone in dimethylsufoxide at a temperature of -78.degree. C. or less is reacted with lithium hydride forming the lithium salt of lawsone; alkylating the lithium salt with an allyl halide; and cyclizing the C-alkylated lawsone derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.