Preparation of salts of pharmaceutical active substances which have acidic groups

US5969181A · kind A · utility

Inventors

• Jorg Breitenbach · Mannheim, DE
• Joerg Rosenberg · Ellerstadt, DE
• Jorg Neumann · Schifferstadt, DE
• Jurgen Zeidler · Mutterstadt, DE
• Dirk Simon · Mutterstadt, DE
• Ralph Diener · Monsheim, DE

Key dates

• Filing date: Jun 10, 1997
• Grant date: Oct 19, 1999
• Expiry date: Jun 10, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/412
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.