Glucose transporter vesicle aminopeptidase
US5972680A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 1995 |
| Grant date | Oct 26, 1999 |
| Priority date | — |
| Expiry date | Sep 19, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/8103
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An aminopeptidase which is a component of GLUT4-containing vesicles in the natural state, and which cleaves insulin. The claimed protein has an apparent molecular weight of approximately 110 kD in its deglycosylated form and a predicted molecular weight of 117,239 Daltons. It includes the amino acid sequences Phe-Ala-Ala-Thr-Gln-Phe-Glu-Pro-Leu-Ala-Ala (SEQ ID NO: 1) and Ile-Leu-Gln-Asn-Gln-Ile-Gln-Gln-Gln-Thr-Arg-Thr-Asp-Glu-Gly-Xaa-Pro-Xaa-Me t (SEQ ID NO: 2, and reacts with antibodies produced against the peptide identified as (SEQ ID NO: 1). It is encoded by the cDNA of FIG. 20 (SEQ. ID NOs. 15 and 16) and is essentially the protein sequence therein described. Modulators of the activity of the aminopeptidase and a method for treating syndromes of insulin resistance, including diabetes, by administration of such a modulator are also claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.