Pyrazoles as human non-pancreatic secretory phospholipase A.sub.2 inhibitors

US5972972A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Edward David Mihelich · Carmel, US
• Tulio Suarez · Indianapolis, US
• Gary Alan Hite · Indianapolis, US
• Peter J. Doman · Bossiney, GB
• Stuart Edmund Willetts · Chapel-en-le-Frith, GB

Key dates

• Filing date: Dec 3, 1997
• Grant date: Oct 26, 1999
• Expiry date: Dec 3, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A class of novel pyrazoles is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.