Ipriflavone preparation process
US5973169A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 22, 1999 |
| Grant date | Oct 26, 1999 |
| Priority date | — |
| Expiry date | Feb 22, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Process for the preparation of ipriflavone consisting in the following steps: PA0 a) reaction of 2,4-dihydroxy-phenyl-benzyl-ketone of formula (II) with ethyl orthoformate in dimethylformamide as solvent and in the presence of a catalyst consisting of morpholine, to yield 7-hydroxyisoflavone of formula (III), PA0 b) separation of product (III) from the reaction residue, PA0 c) alkylation of product (III) from step b) with isopropyl halide to obtain ipriflavone, wherein: PA1 I. step a) is carried out at a temperature ranging from 115 to 120.degree. C. using a 2,4-dihydroxy-phenyl-benzyl-ketone (II) weight/solvent volume (w/v) ratio lower than 1:4; PA1 II. step b) consists in the precipitation of the corresponding salt with dicyclohexylamine of formula (IV). The process yields 7-hydroxyisoflavone (III) in high yields within short reaction times (2 h max.) and ipriflavone with impurity .ltoreq.0.1%. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.