Peptide derived radionuclide chelators
US5976495A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 20, 1996 |
| Grant date | Nov 2, 1999 |
| Priority date | — |
| Expiry date | Mar 20, 2016 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
For use in imaging sites of diagnostic interest within the body, the present invention provides radionuclide chelators of formula (I), wherein X is a linear or branched, saturated or unsaturated C.sub.1-4 alkyl chain that is optionally interrupted by one or two heteroatoms selected from N, O and S; and is optionally substituted by at least one group selected from halogen, hydroxyl, amino, carboxyl C.sub.1-4 alkyl, aryl and C(O)Z; Y is H or a substituent defined by X; X and Y may together form a 5- to 8-membered saturated or unsaturated heterocyclic ring optionally substituted by at least one group selected from halogen, hydroxyl, amino, carboxyl oxo, C.sub.1-4 alkyl, aryl and C(O)Z; R.sup.1 through R.sup.4 are selected independently from H; carboxyl; C.sub.1-4 alkyl; C.sub.1-4 alkyl substituted with a group selected from hydroxyl, amino, sulfhydryl, halogen, carboxyl, C.sub.1-4 alkoxycarbonyl and aminocarbonyl; an alpha carbon side chain of a D- or L-amino acid other than proline; and C(O)Z; R.sup.5 and R.sup.6 are selected independently from H; carboxyl; amino; C.sub.1-4 alkyl; C.sub.1-4 alkyl substituted by hydroxyl, carboxyl or amino; and C(O)Z; R.sup.7 is selected from H and a …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.