High surface area support having bound latex particles containing oxirane groups for immobilization of substances

US5976527A · kind A · utility

Assignee

• Siol, Werner Roehm GmbH Chemishe Fabrik · DE

Inventors

• Werner Siol · Pfungstadt, DE
• Dieter Kraemer · Mainz, DE
• Norbert Suetterlin
• Cornelia Scordialo · Langen (Hessen), DE
• Gerhard Markert · Ober-Ramstadt, DE
• Erwin Schuster · Bechhofen, DE

Key dates

• Filing date: Dec 14, 1992
• Grant date: Nov 2, 1999
• Expiry date: Dec 14, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/815
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A high surface area system is provided with latex particles for immobilization of substances containing nucleophilic groups. The high surface area system is formed by aggregating the latex particles or by bonding the latex particles to a porous support of high surface area. The latex particles contain groups such as oxirane groups that react with the nucleophilic groups. The substances containing nucleophilic groups may be enzymes or proteins such as albumin, immunoglobulins, blood-clotting factors, cell-membrane proteins or peptide hormones. The high surface area system may be used as a sorbent in removing pollutants, as a stationary phase in organic synthesis such as peptide synthesis, and in the therapeutic treatment of a patient.