Altered major histocompatibility complex (MHC) determinant and method of using the determinant

US5976551A · kind A · utility

Assignee

• Institut Pasteur and Institut National de la Sante et de la Recherche Medicale · FR

Inventors

• Estelle Mottez · Paris, FR
• Jean-Pierre Abastado · Singapore, SG
• Philippe Kourilsky · Paris, FR

Key dates

• Filing date: Jun 7, 1995
• Grant date: Nov 2, 1999
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An altered MHC class II determinant comprises .alpha..sub.1, .alpha..sub.2, .beta..sub.1, .beta..sub.2, domains of a mammalian MHC class II locus in which the domains are covalently linked to form a construct comprising the .beta..sub.2 -.alpha..sub.2 -.alpha..sub.1 .beta..sub.1 domains in sequence. The altered class II determinants can be associated with an antigen to elicit an immune response. In addition, the altered determinants may be used to prepare antibodies. The antibodies so produced have various diagnostic and therapeutic uses.