Topical oil-in-water emulsions containing retinoids

US5976555A · kind A · utility

Assignee

• Johnson & Johnson Consumer Products, Inc. · US

Inventors

• Jue-Chen Liu · Neshanic, US
• Jonas C. T. Wang · Plainsboro, US
• Mohammed Yusuf · Edison, US
• Norihiro Yamamoto · Koriyama, JP
• Satoshi Kazama · Sukagawa, JP
• Christopher R. Stahl · Pioneertown, US
• Jean Holland · Doylestown, US
• Kamran Mather · Craydon Court, US
• Margaret Aleles · Gladstone, US
• Sachio Hamada · Farnworth, GB
• Curtis Cole · Glenside, US

Key dates

• Filing date: Mar 1, 1996
• Grant date: Nov 2, 1999
• Expiry date: Mar 1, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.