Proteins having fibrinolytic and coagulation--inhibiting properties

US5976841A · kind A · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stephan Wnendt · Aachen, DE
• Regina Heinzel-Wieland · Darmstadt, DE
• Gerd J. Steffens · Aachen, DE

Key dates

• Filing date: Nov 17, 1995
• Grant date: Nov 2, 1999
• Expiry date: Nov 17, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Proteins having fibrinolytic and coagulation-inhibiting properties which are linked at the N- and/or C-terminal end of the plasminogen-activating amino acid sequence to a thrombin- or factor Xa-inhibiting amino acid sequence. The proteins, which are produced by genetic engineering, are useful as thrombolytic agents.