Composite antibodies of human subgroup IV light chain capable of binding to TAG-72

US5976845A · kind A · utility

Assignee

• THE DOW CHEMICAL COMPANY · US

Inventors

• Peter Mezes · Old Lyme, US
• Ruth A. Richard · Midland, US
• Kimberly Johnson · New York, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Nov 2, 1999
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention concerns a subset of composite Hum4 V.sub.L, V.sub.H antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V.sub.L segments derived from the human subgroup IV germline gene, and (2) a V.sub.H segment which is capable of combining with the V.sub.L to form a three dimensional structure having the ability to bind TAG-72. In vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.