Method of identifying potential fungicides using dihydroorotate dehydrogenase inhibition assay
US5976848A · kind A · utility
12Cited by
1References
8Claims
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Key dates
| Filing date | Jan 30, 1992 |
| Grant date | Nov 2, 1999 |
| Priority date | — |
| Expiry date | Jan 30, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y103/05002
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Dihydroorotate dehydrogenase (DHOD) inhibititon assays are utilized in a method for identifying new fungicides; DHOD inhibitors are useful in fungicidal methods and compositions. Resistance genes that are mutants of the wild-type Aspergillus nidulans dihydroorotate dehydrogenase gene have been isolated and found to impart resistance to certain DHOD inhibitors. The resistance genes are useful as selectable markers in fungi. The wild-type gene is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.