Bacterial nitroreductase for the reduction of CB1954 and analogues thereof to a cytotoxic form
US5977065A · kind A · utility
6Cited by
4References
11Claims
0Family size
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Key dates
| Filing date | Jun 1, 1998 |
| Grant date | Nov 2, 1999 |
| Priority date | — |
| Expiry date | Jun 1, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R.sup.1 NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.2 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.