Inositol polyphosphate derivatives and methods of using same

US5977078A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Alexis Traynor-Kaplan · North Bend, US
• Carsten Schultz · Heidelberg, DE
• Stefan Roemer · Bremen, DE
• Christoph Stadler · Bremen, DE
• Marco Rudolf · Visselhövede, DE

Key dates

• Filing date: Sep 19, 1997
• Grant date: Nov 2, 1999
• Expiry date: Sep 19, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/117
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a s…