Patent · US Expired

Sulfated disaccharide inhibitors of selectins, methods for synthesis and therapeutic use

US5977080A · kind A · utility

42Cited by

2References

23Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Steven D. Rosen · San Francisco, US
Carolyn R. Bertozzi · Berkeley, US

Key dates

Filing date	Jan 8, 1998
Grant date	Nov 2, 1999
Priority date	—
Expiry date	Jan 8, 2018

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H11/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Sulfated disaccharides characterized by the ability to inhibit the binding of selectin to its physiologically-relevant ligand are disclosed. Included are efficient and inexpensive methods for producing the sulfated disaccharides, and methods for their therapeutic use and in in vivo and in vitro assays.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.