Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity

US5977101A · kind A · utility

Assignee

• SmithKline Beecham Limited · US

Inventors

• Fadia E. Ali · Cherry Hill, US
• William E. Bondinell · Wayne, US
• William F. Huffman · Malvern, US
• M. Amparo Lago · Audubon, US
• Richard M. Keenan · Malvern, US
• Chet Kwon · King of Prussia, US
• William Henry Miller · Collegeville, US
• Thomas Nguyen · Newbury Park, US
• Dennis T. Takata · Flourtown, US

Key dates

• Filing date: Dec 20, 1996
• Grant date: Nov 2, 1999
• Expiry date: Dec 20, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporsis.