Sulfonamide inhibitors of matrix metalloproteinases
US5977141A · kind A · utility
2Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 13, 1998 |
| Grant date | Nov 2, 1999 |
| Priority date | — |
| Expiry date | May 13, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Sulfonamide compounds are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes using the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.