Patent · US Expired

Methods of synthesizing GM3

US5977329A · kind A · utility

0Cited by

2References

12Claims

0Family size

Assignee

LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

Richard Schmidt · Konstanz, DE
Julio C. Castro-Palomino · Konstanz, DE
Gerd Ritter · New York, US
Lloyd J. Old · New York, US

Key dates

Filing date	Feb 17, 1998
Grant date	Nov 2, 1999
Priority date	—
Expiry date	Feb 17, 2018

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H3/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention describes an improved method for making monosialoganglioside GM3 and its intermediates. Following reaction of a neuraminic acid donor and a lactose acceptor in the presence of an acid catalyst, the .alpha. and .beta. isomers of GM3 are formed. The .alpha. isomer is converted to a lactone, via action of a ring forming basic catalyst, which is then separable from the .beta. isomer. The lactone is then treated with a basic catalyst in the presence of an alcohol, to form GM3 or a GM3 intermediate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.