Cationic lipids and methods of use therefor
US5980935A · kind A · utility
15Cited by
7References
16Claims
0Family size
Inventors
Key dates
| Filing date | May 15, 1996 |
| Grant date | Nov 9, 1999 |
| Priority date | — |
| Expiry date | May 15, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6911
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to a non-toxic lipid conjugated with a cationic amino acid containing a guanidino group. Specifically, the naturally-occuring lipid DOPE is combined with the naturally-occurring amino acid Arginine. These compounds are useful for encapsulating and delivering pharmaceuticals and poly and oligonucleotides. These compound improve over current compounds, because they are composed of non-toxic and, in the case of Arg-DOPE, natural components, and therefore result in minimal unwanted side effects. Methods of use of the cationic lipids are also claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.