Genetic assay
US5981174A · kind A · utility
15Cited by
1References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 4, 1993 |
| Grant date | Nov 9, 1999 |
| Priority date | — |
| Expiry date | Nov 4, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Polymorphisms at positions 100, 271, 281, 294, 408, 506 or 1432 of the cytochrome P450 enzyme bufuralol-1'-hydroxylase are indicative of the extensive metaboliser/poor metaboliser phenotypes and can be detected using known methods such as amplification of the DNA with the polymerase chain reaction, followed by digestion with a suitable restriction enzyme and analysis by gel electrophoresis. The EM/PM phenotype is relevant to calculating safe or effective drug doses for individuals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.