Isolated nucleic acid molecules useful as leukemia markers and in breast cancer prognosis and encoded polypeptides
US5981218A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jul 31, 1996 |
| Grant date | Nov 9, 1999 |
| Priority date | — |
| Expiry date | Jul 31, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/112
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to four novel human genes amplified and overexpressed in breast carcinoma and located on the q11-q21.3 region of chromosome 17. The four novel genes are useful in breast cancer prognosis. The present invention also relates to a fifth novel human gene expressed in breast carcinoma and located on chromosome 6q22-q23. A sixth novel gene is also described that is the murine homolog of the human D52 gene. The genes and gene fragments of the present invention are themselves useful as DNA and RNA probes for gene mapping by in situ hybridization with chromosomes and for detecting gene expression in human tissues (including breast and lymph node tissues) by Northern blot analysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.